Dr. Siriporn Damrongsakkul
ดร. ศิริพร ดำรงค์ศักดิ์กุล
Education : Ph.D. (Polymer Science), University of London, 1996 M.Sc (Advance Chemical Engineering), University of London, 1992 B.E. in Chemical Engineering Chulalongkorn University, 1990
Address
Department of Chemical Engineering, 9th Floor, Building 4,
Faculty of Engineering, Chulalongkorn University, Bangkok 10330, Thailand
siriporn.d@chula.ac.th
02-218-6862
02-218-6877
Research Interest
My research focuses on polymer blends and composites, biodegradable polymers for biomedical applications, property modification of polymer.
Highlights
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Development of Thai silk protein as a biomaterial in tissue engineering and drug delivery applications
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Thai silk fibroin, the main protein in Thai silk cocoon, was extracted and fabricated into various forms in order to apply in tissue engineering and drug delivery, for example, Thai silk fibroin-based scaffolds to be used as bone substitutes, microspheres and hydrogels to be used as drug delivery systems.
Expertise
Biomaterials for tissue engineering, drug delivery and controlled release system
Research Groups
Publications
Panchamanee, J., Laomeephol, C., Luckanagul, J.A., Wang, Q., Damrongsakkul, S. In vitro biological activities of the flexible and virus nanoparticle-decorated silk fibroin-based films, 2022, International Journal of Biological Macromolecules, 216, 437-445.
Laomeephol, C., Vasuratna, A., Ratanavaraporn, J., Kanokpanont, S., Luckanagul, J.A., Humenik, M., Scheibel, T., Damrongsakkul, S. Impacts of blended bombyx mori silk fibroin and recombinant spider silk fibroin hydrogels on cell growth, 2021, Polymers, 13 (23), 4182.
Thitiset, T., Damrongsakkul, S., Yodmuang, S., Leeanansaksiri, W., Apinun, J., Honsawek, S. A novel gelatin/chitooligosaccharide/demineralized bone matrix composite scaffold and periosteum-derived mesenchymal stem cells for bone tissue engineering, 2021, Biomaterials Research 25(1), 19.
Pudkon, W., Laomeephol, C., Damrongsakkul, S., Kanokpanont, S., Ratanavaraporn, J. Comparative study of silk fibroin‐based hydrogels and their potential as material for 3‐dimensional (3d) printing, 2021, Molecules 26(13), 3887.
Duangpakdee, A., Laomeephol, C., Jindatip, D., Thongnuek, P., Ratanavaraporn, J., Damrongsakkul, S. Crosslinked silk fibroin/gelatin/hyaluronan blends as scaffolds for cell-based tissue engineering, 2021, Molecules 26(11), 3191.
Manissorn, J., Wattanachai, P., Tonsomboon, K., Bumroongsakulsawat, P., Damrongsakkul, S., Thongnuek, P. Osteogenic enhancement of silk fibroin-based bone scaffolds by forming hybrid composites with bioactive glass through GPTMS during sol-gel process, 2021, Materials Today Communications 26, 101730.
Umprasert, P., Damrongsakkul, S., Yodmuang, S., Ratanavaraporn, J. Effect of silver sulfadiazine and metallic ions on properties of thai silk fibroin/gelatin films for anti-bacterial applications, 2021, Engineering Journal 25(5), 13-20.
Manissorn, J.| Wattanachai, P.| Tonsomboon, K.| Bumroongsakulsawat, P.| Damrongsakkul, S.| Thongnuek, P. Osteogenic enhancement of silk fibroin-based bone scaffolds by forming hybrid composites with bioactive glass through GPTMS during sol-gel process, 2020, Materials Today Communications, 101730.
Laomeephol, C., Ferreira, H., Kanokpanont, S., Neves, M.N., Kobayashi, H., Damrongsakkul, S., Dual-functional liposomes for curcumin delivery and accelerating silk fibroin hydrogel formation , 2020, International Journal of Pharmaceutics 589, 119844.
Laomeephol, C., Ferreira, H., Yodmuang, S., Reis, L.R., Damrongsakkul, S., Neves, M.N. Exploring the gelation mechanisms and cytocompatibility of gold (III)-mediated regenerated and thiolated silk fibroin hydrogels , 2020, Biomolecules 10(3), 466.
Chancheewa B., Buranapraditkun S., Laomeephol C., Rerknimitr P., Kanokpanont S., Damrongsakkul S., Klaewsongkram J. In vitro immune responses of human peripheral blood mononuclear cells to silk fibroin: IL-10 stimulated anti-inflammatory and hypoallergenic properties. 2020. Materials Today Communications, 24, 101044.
Laomeephol, C., Guedes, M., Ferreira, H., Reis, R. L., Kanokpanont, S., Damrongsakkul, S., Neves, N. M. Phospholipid‐induced silk fibroin hydrogels and their potential as cell carriers for tissue regeneration. 2020. Journal of tissue engineering and regenerative medicine, 14 (1), 160-172.
Chantong, N., Damrongsakkul, S., Ratanavaraporn, J. Gelation Process and Physicochemical Properties of Thai Silk Fibroin Hydrogels Induced by Various Anionic Surfactants for Controlled Release of Curcumin. (2019). Journal of Surfactants and Detergents, 22 (6), 1395-1407.
Prasertsung, I., Aroonraj, K., Kamwilaisak, K., Saito, N., Damrongsakkul, S. Production of reducing sugar from cassava starch waste (CSW) using solution plasma process (SPP). 2019. Carbohydrate polymers, 205, 472-479.
Ratanavaraporn, J., Chuma, N., Kanokpanont, S., Damrongsakkul, S. Beads fabricated from alginate, hyaluronic acid, and gelatin using ionic crosslinking and layer‐by‐layer coating techniques for controlled release of gentamicin. 2019. Journal of Applied Polymer Science, 136 (1), 46893.
Kaewprasit, K., Kobayashi, T., Damrongsakkul, S. Thai silk fibroin gelation process enhancing by monohydric and polyhydric alcohols. (2018). International journal of biological macromolecules, 118, 1726-1735.
Malay, A., Sato, R., Yazawa, K., Watanabe, H., Ifuku, N., Masunaga, H., Hikima, T., Guan, J., Mandal, B., Damrongsakkul, S., Numata, K. Relationships between physical properties and sequence in silkworm silks. 2016. Scientific Reports 6
Sahapaibounkit, P., Prasertsung, I., Mongkolnavin, R., Wong, C., Damrongsakkul, S. A two-step method using air plasma and carbodiimide crosslinking to enhance the biocompatibility of polycaprolactone. 2016. Journal of Biomedical Materials Research – Part B Applied Biomaterials
Sinlapabodin S., Amornsudthiwat P., Damrongsakkul S., Kanokpanont S. An axial distribution of seeding, proliferation, and osteogenic differentiation of MC3T3-E1 and rat bone marrow-derived mesenchymal stem cells across a 3D Thai silk fibroin/gelatin/hydroxyapatite scaffold in a perfusion bioreactor. 2016. Materials Science & Engineering C 58 , 960-970.
Sinlapabodin, S., Amornsudthiwat, P., Damrongsakkul, S., Kanokpanont, S. An axial distribution of seeding, proliferation, and osteogenic differentiation of MC3T3-E1 cells and rat bone marrow-derived mesenchymal stem cells across a 3D Thai silk fibroin/gelatin/hydroxyapatite scaffold in a perfusion bioreactor. 2016. Materials Science and Engineering C 58 , 960-970.
Lerdchai, K., Kitsongsermthon, J., Ratanavaraporn, J., Kanokpanont, S., Damrongsakkul, S. Thai Silk Fibroin/Gelatin Sponges for the Dual Controlled Release of Curcumin and Docosahexaenoic Acid for Anticancer Treatment. 2016. Journal of Pharmaceutical Sciences 105 (1) , 221-230.
Tantiplapol, T., Singsawat, Y., Narongsil, N., Damrongsakkul, S., Saito, N., Prasertsung, I. Influences of solution plasma conditions on degradation rate and properties of chitosan. 2015. Innovative Food Science and Emerging Technologies 32 , 116-120.
Amornsudthiwat P., Nitschke M., Zimmmermann R., Friedrichs J., Grundke K., Pöschel K., Damrongsakkul S., Werner C. A comprehensive characterization of well-defined silk fibroin surfaces: Towards multi-technique studies of surface modification effects. 2015. Biointerphases 10 (2) , 029509-1-029509-10.
Lerdchai K., Kitsongsermthon J., Ratanavaraporn J., Kanokpanont S., Damrongsakkul S. Thai Silk Fibroin/Gelatin Sponges for the Dual Controlled Release of Curcumin and DHA for Anti-cancer Treatment. 2015. Journal of Pharmaceutical Sciences
Dararutana, C., Ratanavaraporn, J., Honsawek, S., Kanokpanont, S., Damrongsakkul, S. Characteristics and osteoconductivity of bone composite scaffolds made of Thai silk fibroin, gelatin and inorganic compounds: A comparative study of β-tricalcium phosphate and hydroxyapatite. 2015. Macromolecular Symposia 354 (1) , 258-264.
Ratanavaraporn, J., Kanokpanont, S., Damrongsakkul, S. The development of injectable gelatin/silk fibroin microspheres for the dual delivery of curcumin and piperine. 2014. Journal of Materials Science: Materials in Medicine 25 (2) , 401-410.
Rimdusit, S., Wongmanit, P., Damrongsakkul, S., Saramas, D., Jubsilp, C., Dueramae, I. Characterizations of poly(vinyl chloride)/acrylonitrile styrene acrylate blends for outdoor applications. 2014. Engineering Journal 18 (1) , 105-118.
Wong, C., Chin, O., Yap, S., Tin, C., Kausik, S., Mongkolnavin, R., Damrongsakkul, S., Subedi, D. Cost effective plasma technology for bio-medical materials treatment. 2014. AIP Conference Proceedings 1588 , 109-114.
Amornsudthiwat, P., Damrongsakkul, S. Oxygen plasma etching of silk fibroin alters surface stiffness: A cell-substrate interaction study. 2014. Plasma Processes and Polymers 11 (8) , 763-776.
Kaewprasit, K., Promboon, A., Kanokpanont, S., Damrongsakkul, S. Physico-chemical properties and in vitro response of silk fibroin from various domestic races. 2014. Journal of Biomedical Materials Research – Part B Applied Biomaterials 102 (8) , 1639-1647.
Amornsudthiwat, P., Mongkolnavin, R., Kanokpanont, S., Panpranot, J., Wong, C., Damrongsakkul, S. Improvement of early cell adhesion on Thai silk fibroin surface by low energy plasma. 2013. Colloids and Surfaces B: Biointerfaces 111 , 579-586.
Prasertsung, I., Kanokpanont, S., Mongkolnavin, R., Wong, C., Panpranot, J., Damrongsakkul, S. Comparison of the behavior of fibroblast and bone marrow-derived mesenchymal stem cell on nitrogen plasma-treated gelatin films. 2013. Materials Science and Engineering C 33 (7) , 4475-4479.
Prasertsung, I., Damrongsakkul, S., Saito, N. Degradation of β-chitosan by solution plasma process (SPP). 2013. Polymer Degradation and Stability 98 (10) , 2089-2093.
Prasertsung, I., Damrongsakkul, S., Saito, N. Crosslinking of a gelatin solutions induced by pulsed electrical discharges in solutions. 2013. Plasma Processes and Polymers 10 (9) , 792-797.
Kulpreechanan, N., Bunaprasert, T., Damrongsakkul, S., Kanokpanont, S., Rangkupan, R. Effect of polycaprolactone electrospun fiber size on L929 cell behavior. 2013. Advanced Materials Research 701 , 420-424.
Somvipart, S., Kanokpanont, S., Rangkupan, R., Ratanavaraporn, J., Damrongsakkul, S. Development of electrospun beaded fibers from Thai silk fibroin and gelatin for controlled release application. 2013. International Journal of Biological Macromolecules 55 , 176-184.
Kanokpanont, S., Damrongsakkul, S., Ratanavaraporn, J., Aramwit, P. Physico-chemical properties and efficacy of silk fibroin fabric coated with different waxes as wound dressing. 2013. International Journal of Biological Macromolecules 55 , 88-97.
Vorrapakdee, R., Kanokpanont, S., Ratanavaraporn, J., Waikakul, S., Charoenlap, C., Damrongsakkul, S. Modification of human cancellous bone using Thai silk fibroin and gelatin for enhanced osteoconductive potential. 2013. Journal of Materials Science: Materials in Medicine 24 (3) , 735-744.
Thitiset, T., Damrongsakkul, S., Bunaprasert, T., Leeanansaksiri, W., Honsawek, S. Development of collagen/demineralized bone powder scaffolds and periosteum-derived cells for bone tissue engineering application. 2013. International Journal of Molecular Sciences 14 (1) , 2056-2071.
Kanokpanont, S., Damrongsakkul, S., Ratanavaraporn, J., Aramwit, P. An innovative bi-layered wound dressing made of silk and gelatin for accelerated wound healing. 2012. International Journal of Pharmaceutics 436 (1-2) , 141-153.
Prasertsung, I., Kanokpanont, S., Mongkolnavin, R., Wong, C., Panpranot, J., Damrongsakkul, S. Plasma enhancement of in vitro attachment of rat bone-marrow-derived stem cells on cross-linked gelatin films. 2012. Journal of Biomaterials Science, Polymer Edition 23 (11) , 1485-1504.
Wongputtaraksa, T., Ratanavaraporn, J., Pichyangkura, R., Damrongsakkul, S. Surface modification of Thai silk fibroin scaffolds with gelatin and chitooligosaccharide for enhanced osteogenic differentiation of bone marrow-derived mesenchymal stem cells. 2012. Journal of Biomedical Materials Research – Part B Applied Biomaterials
Rimdusit, S., Atthakorn, D., Damrongsakkul, S., Saramas, D., Tiptipakorn, S. Mechanical, thermal, and water uptake characteristics of woodflour-filled polyvinyl chloride/acrylonitrile butadiene styrene blends. 2012. Journal of Applied Polymer Science 124 (2) , 943-950.
Prasertsung, I., Damrongsakkul, S., Terashima, C., Saito, N., Takai, O. Preparation of low molecular weight chitosan using solution plasma system. 2012. Carbohydrate Polymers 87 (4) , 2745-2749.
Jetbumpenkul, P., Amornsudthiwat, P., Kanokpanont, S., Damrongsakkul, S. Balanced electrostatic blending approach – An alternative to chemical crosslinking of Thai silk fibroin/gelatin scaffold. 2012. International Journal of Biological Macromolecules 50 (1) , 7-13.
Kanokpanont, S., Damrongsakkul, S., Thitiwuthikiat, P. Biomedical application of Thai silks. 2011. BMEiCON-2011 – 4th Biomedical Engineering International Conference , 286-289.
Rimdusit, S., Damrongsakkul, S., Wongmanit, P., Saramas, D., Tiptipakorn, S. Characterization of coconut fiber-filled polyvinyl chloride/acrylonitrile styrene acrylate blends. 2011. Journal of Reinforced Plastics and Composites 30 (20) , 1691-1702.
Ratanavaraporn, J., Damrongsakkul, S., Kanokpanont, S., Yamamoto, M., Tabata, Y. Osteogenic differentiation of bone-marrow-derived stem cells cultured with mixed gelatin and chitooligosaccharide scaffolds. 2011. Journal of Biomaterials Science, Polymer Edition 22 (8) , 1083-1098.
Prasertsung, I., Mongkolnavin, R., Damrongsakkul, S., Wong, C. Surface modification of dehydrothermal crosslinked gelatin film using a 50Hz oxygen glow discharge. 2010. Surface and Coatings Technology 205 (SUPPL. 1)
Tungtasana, H., Shuangshoti, S., Shuangshoti, S., Kanokpanont, S., Kaplan, D., Bunaprasert, T., Damrongsakkul, S. Tissue response and biodegradation of composite scaffolds prepared from Thai silk fibroin, gelatin and hydroxyapatite. 2010. Journal of Materials Science: Materials in Medicine 21 (12) , 3151-3162.
Ratanavaraporn, J., Rangkupan, R., Jeeratawatchai, H., Kanokpanont, S., Damrongsakkul, S. Influences of physical and chemical crosslinking techniques on electrospun type A and B gelatin fiber mats. 2010. International Journal of Biological Macromolecules 47 (4) , 431-438.
Okhawilai, M., Rangkupan, R., Kanokpanont, S., Damrongsakkul, S. Preparation of Thai silk fibroin/gelatin electrospun fiber mats for controlled release applications. 2010. International Journal of Biological Macromolecules 46 (5) , 544-550.
Ratanavaraporn, J., Kanokpanont, S., Tabata, Y., Damrongsakkul, S. Modulation of in vitro attachment, proliferation and osteogenic differentiation of rat bone-marrow-derived stem cells using different molecular mass chitosans and their blends with gelatin. 2010. Journal of Biomaterials Science, Polymer Edition 21 (8-9) , 979-996.
Vachiraroj, N., Damrongsakkul, S., Kanokpanont, S. Gelatin/hydroxyapatite scaffolds: Studies on adhesion, growth and differentiation of Mesenchymal stem cells. 2010. Advanced Materials Research 93-94 , 121-124.
Aramwit, P., Damrongsakkul, S., Kanokpanont, S., Srichana, T. Properties and antityrosinase activity of sericin from various extraction methods. 2010. Biotechnology and Applied Biochemistry 55 (2) , 91-98.
Prasertsung, I., Mongkolnavin, R., Kanokpanont, S., Damrongsakkul, S. The effects of pulsed inductively coupled plasma (PICP) on physical properties and biocompatibility of crosslinked gelatin films. 2010. International Journal of Biological Macromolecules 46 (1) , 72-78.
Vachiraroj, N., Ratanavaraporn, J., Damrongsakkul, S., Pichyangkura, R., Banaprasert, T., Kanokpanont, S. A comparison of Thai silk fibroin-based and chitosan-based materials on in vitro biocompatibility for bone substitutes. 2009. International Journal of Biological Macromolecules 45 (5) , 470-477.
Tritanipakul, S., Kanokpanont, S., Kaplan, D., Damrongsakkul, S. Morphology and In Vitro Biocompatibility of Hydroxyapatite-Conjugated Gelatin/Thai Silk Fibroin Scaffolds. 2009. IFMBE Proceedings 23 , 1377-1380.
Ratanavaraporn, J., Kanokpanont, S., Tabata, Y., Damrongsakkul, S. Response of Bone Marrow-derived Stem Cells (MSCs) on Gelatin/Chitosan and Gelatin/Chitooligosaccharide films. 2009. IFMBE Proceedings 23 , 1301-1304.
Prasertsung, I., Kanokpanont, S., Mongkolnavin, R., Damrongsakkul, S. The Effects of Pulse Inductively Coupled Plasma on the Properties of Gelatin. 2009. IFMBE Proceedings 23 , 1217-1219.
Ratanavaraporn, J., Kanokpanont, S., Tabata, Y., Damrongsakkul, S. Growth and osteogenic differentiation of adipose-derived and bone marrow-derived stem cells on chitosan and chitooligosaccharide films. 2009. Carbohydrate Polymers 78 (4) , 873-878.
Chamchongkaset, J., Kanokpanont, S., Kaplan, D., Damrongsakkul, S. Modification of thai silk fibroin scaffolds by gelatin conjugation for tissue engineering. 2008. Advanced Materials Research 55-57 , 685-688.
Ratanavaraporn, J., Kanokpanont, S., Tabata, Y., Damrongsakkul, S. Effects of acid type on physical and biological properties of collagen scaffolds. 2008. Journal of Biomaterials Science, Polymer Edition 19 (7) , 945-952.
Rimdusit, S., Jingjid, S., Damrongsakkul, S., Tiptipakorn, S., Takeichi, T. Biodegradability and property characterizations of Methyl Cellulose: Effect of nanocompositing and chemical crosslinking. 2008. Carbohydrate Polymers 72 (3) , 444-455.
Prasertsung, I., Kanokpanont, S., Bunaprasert, T., Thanakit, V., Damrongsakkul, S. Development of acellular dermis from porcine skin using periodic pressurized technique. 2008. Journal of Biomedical Materials Research – Part B Applied Biomaterials 85 (1) , 210-219.
Damrongsakkul, S., Ratanathammapan, K., Komolpis, K., Tanthapanichakoon, W. Enzymatic hydrolysis of rawhide using papain and neutrase. 2008. Journal of Industrial and Engineering Chemistry 14 (2) , 202-206.
Tiptipakorn, S., Damrongsakkul, S., Ando, S., Hemvichian, K., Rimdusit, S. Thermal degradation behaviors of polybenzoxazine and silicon-containing polyimide blends. 2007. Polymer Degradation and Stability 92 (7) , 1265-1278.
Tangsadthakun, C., Kanokpanont, S., Sanchavanakit, N., Pichyangkura, R., Banaprasert, T., Tabata, Y., Damrongsakkul, S. The influence of molecular weight of chitosan on the physical and biological properties of collagen/chitosan scaffolds. 2007. Journal of Biomaterials Science, Polymer Edition 18 (2) , 147-163.
Pitpreecha, S., Damrongsakkul, S. Hydrolysis of raw hide using proteolytic enzyme extracted from papaya latex. 2006. Korean Journal of Chemical Engineering 23 (6) , 972-976.
Jubsilp, C., Damrongsakkul, S., Takeichi, T., Rimdusit, S. Curing kinetics of arylamine-based polyfunctional benzoxazine resins by dynamic differential scanning calorimetry. 2006. Thermochimica Acta 447 (2) , 131-140.
Atimuttigul, V., Damrongsakkul, S., Tanthapanichakoon, W. Effects of oil type on the properties of short oil alkyd coating materials. 2006. Korean Journal of Chemical Engineering 23 (4) , 672-677.
Takeshita, H., Shiomi, T., Suzuki, T., Sato, T., Miya, M., Takenaka, K., Wacharawichanant, S., Damrongsakkul, S., Rimdusit, S., Thongyai, S., Taepaisitphongse, V. Miscibility in blends of linear and branched poly(ethylene oxide) with methacrylate derivative random copolymers and estimation of segmental χ parameters. 2005. Polymer 46 (25) , 11463-11469.
Rimdusit, S., Pirstpindvong, S., Tanthapanichakoon, W., Damrongsakkul, S. Toughening of polybenzoxazine by alloying with urethane prepolymer and flexible epoxy: A comparative study. 2005. Polymer Engineering and Science 45 (3) , 288-296.
Damrongsakkul, S., Sinweeruthai, R., Higgins, J. Processability and chemical resistance of the polymer blend of thermoplastic polyurethane and polydimethylsiloxane. 2003. Macromolecular Symposia 198 , 411-419.